- Navigate to C:/Users/%username%/Documents/My Games/ (this is the default location)
- Locate the folder of your game (for instance, Rainbow Six: Siege or Ghost Recon: Wildlands).
- Then, rename this folder (for instance, Rainbow Six: Siege_old or Ghost Recon: Wildlands_old)
- Finally, make sure that UPLAY IS RUNNING WITH ADMIN RIGHTS and relaunch the game. You will have to set your key mapping one last time but it shouldn't reset after the next restart.